The National Institutes of Health have in recent years funded dangerous gain-of-function research on bat coronaviruses at the biosafety level 4 (BSL4) laboratory in Wuhan, China
Gain of function research refers to research in which pathogenicity or transmissibility of pathogens is enhanced to make a pathogen more dangerous to humans
To gain entry into a cell, the virus must first bind to an ACE2 or CD147 receptor. Next, the S2 spike protein subunit must be proteolytically cleaved. Without this protein cleavage, the virus would be unable to enter
There are several enzymes that cleave spike proteins, including plasmin, which also degrades fibrin. When a blood clot is dissolved, a byproduct called D-dimer is created, and many patients with serious COVID-19 infection have elevated D-dimer, which is indicative of blood clots
Another protein cleaver is furin, and the presence of a furin cleavage site on SARS-CoV-2 is “the smoking gun” that proves SARS-CoV-2 was lab-created
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